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Aptamers 2018
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Review Article J RNAi Gene Silenc (February 2006), 2(1), 118-125 doi: jrgsxx Published online: 12 January 2006 Full Text: (html | pdf ~243kb | refs) Manipulating and enhancing the RNAi response Peter I Joyce, Joseph M Gallagher and Patricia E Kuwabara * Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK *Correspondence to: Patricia E Kuwabara, Email: P.Kuwabara@bristol.ac.uk, Tel: + 44 117 3317275, Fax: + 44 117 9288274 Received: 20 December...
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Editorial J RNAi Gene Silenc (February 2006), 2(1), 105-106 doi: jrgsxx Published online: 16 December 2005 Full Text: (html | pdf ~117kb | refs) P-Bodies and RNAi: The missing link? Derek M Dykxhoorn CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA Correspondence to: Derek M Dykxhoorn, Email: dykxhoor@cbr.med.harvard.edu, Tel: +617 278 3109 Received: 06 December 2005 © Copyright The Author —————————————————————————————————————– For many years studies on the regulation of gene expression have focused on...
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Review Article J RNAi Gene Silenc (February 2006), 2(1), 109-117 doi: jrgsxx Published online: 30 November 2005 Full Text: (html | pdf ~392kb | refs) Designer siRNAs to overcome the challenges from the RNAi pathway Sumedha D Jayasena Amgen Inc., Oncology Research, One Amgen Center Drive, Thousand Oaks, CA 91320, USA Correspondence to: Sumedha D Jayasena, Email: sumedhaj@amgen.com, Tel: +805 447 5627, Fax: +805 499 2751 Received: 13 October 2005, Revised: 7 November 2005, Accepted: 21 November 2005 © Copyright The...
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News and Views J RNAi Gene Silenc (October 2005), 1(2), 52-53 doi: jrgsxx Published online: 14 October 2005 Full Text: (html | pdf ~96kb | refs) Progress in targeted delivery of therapeutic siRNA —————————————————————————————————————– Three recent studies have demonstrated rapid advancements in overcoming the challenges facing application of RNA interference based therapeutics. Researchers at SiRNA Therapeutics (Boulder, USA) and Caltech and Children`s Hopsital (Los Angeles) have shown that packaging in colloidal particles significantly enhances...
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News and Views J RNAi Gene Silenc (October 2005), 1(2), 54-55 doi: jrgsxx Published online: 14 October 2005 Full Text: (html | pdf ~96kb | refs) Anti-miRNA anti-virals make antisense —————————————————————————————————————– Whilst talk of RNA interference may predominate at both academic and industry conferences, the role for DNA antisense oligonculeotide technology has far from been diminished. RNAi based therapeutic strategies laud the appropriation of an endogenous gene regulation pathway as a primary advantage of...
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