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J Venom Res
Open-access
Aptamers
Open-access
Aptamers 2019
03-04 April 2019, Oxford
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Review Article J RNAi Gene Silenc (February 2006), 2(1), 109-117 doi: jrgsxx Published online: 30 November 2005 Full Text: (html | pdf ~392kb | refs) Designer siRNAs to overcome the challenges from the RNAi pathway Sumedha D Jayasena Amgen Inc., Oncology Research, One Amgen Center Drive, Thousand Oaks, CA 91320, USA Correspondence to: Sumedha D Jayasena, Email: sumedhaj@amgen.com, Tel: +805 447 5627, Fax: +805 499 2751 Received: 13 October 2005, Revised: 7 November 2005, Accepted: 21 November 2005 © Copyright The...
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News and Views J RNAi Gene Silenc (October 2005), 1(2), 52-53 doi: jrgsxx Published online: 14 October 2005 Full Text: (html | pdf ~96kb | refs) Progress in targeted delivery of therapeutic siRNA —————————————————————————————————————– Three recent studies have demonstrated rapid advancements in overcoming the challenges facing application of RNA interference based therapeutics. Researchers at SiRNA Therapeutics (Boulder, USA) and Caltech and Children`s Hopsital (Los Angeles) have shown that packaging in colloidal particles significantly enhances...
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News and Views J RNAi Gene Silenc (October 2005), 1(2), 54-55 doi: jrgsxx Published online: 14 October 2005 Full Text: (html | pdf ~96kb | refs) Anti-miRNA anti-virals make antisense —————————————————————————————————————– Whilst talk of RNA interference may predominate at both academic and industry conferences, the role for DNA antisense oligonculeotide technology has far from been diminished. RNAi based therapeutic strategies laud the appropriation of an endogenous gene regulation pathway as a primary advantage of...
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Review Article J RNAi Gene Silenc (October 2005), 1(2), 56-65 doi: jrgsxx Published online: 14 October 2005 Full Text: (html | pdf ~319kb | refs) A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs Olivier ter Brake and Ben Berkhout* Department of Human Retrovirology, University of Amsterdam, Academic Medical Center (AMC), Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands *Correspondence to: Ben Berkhout, Email: b.berkhout@amc.uva.nl, Tel:...
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Research Article J RNAi Gene Silenc (October 2005), 1(2), 79-87 doi: jrgsxx Published online: 14 October 2005 Full Text: (html | pdf ~1580kb | refs) RNAi induced in mammalian and Drosophila cells via transfection of dimers and trimers of small interfering RNAs Kumiko Ui-Tei †‡*, Shuhei Zenno †, Aya Juni †‡ and Kaoru Saigo † † Department of Biophysics and Biochemistry, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan...
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