Welcome to Aptamers 2015

Dear Colleagues:

We are delighted to announce our second Oxford symposium on aptamers, Aptamers 2015, which is designed to bring together academic and industrial aptamer researchers and solution providers. The symposium will address therapeutic, diagnostic, analytical as well as basic research applications of aptamers and invites proposals for podium and poster presentation. Please contact us on AptamersOxford@gmail.com, should you require any further information.

Aptamers 2015 will be co-hosted with our 1st symposium on antisense and catalytic oligonucleotides, Oligo 2015, on 30 March 2015.

We cordially invite you to the beautiful and historical city of Oxford to what we hope will be a memorable meeting.

Dr Vittorio de FranciscisVittorio
(Symposium Chair)
Research Director
CNR Institute of Experimental Endocrinology and Oncology



Day 1, Tuesday, 31 March 2015

08.30-09.20: Registration, welcome coffee and networking

09.20: Housekeeping announcements

09.25: Welcome by the symposium chair

09.30: Dr David Bunka
Co-director and CTO of Aptamer Solutions and Aptamer Diagnostics Ltd, UK
Title: Aptamers: Where’ve we been, where are we now and where are we going

10.00: Professor Said Ismail
Head, Molecular Biology Research Laboratory, Medical School, University of Jordan, and, Head, Molecular Diagnostics Lab, Jordan University Hospital, Amman, Jordan
Title: Aptamers as Potential Tyrosine Kinase Inhibitors

10.30: Professor Dr Ulrich Hahn
University of Hamburg, Department Chemistry, Institute for Biochemistry and Molecular Biology, Martin-Luther-King-Platz 6, Hamburg, Germany
Title:  Cell surface protein specific aptamers for diagnosis, therapy and cargo delivery into target cells

11.00: Refreshment break, posters, exhibition, networking

11.30: Dr Sarah Shigdar
Lecturer in Medical Sciences, Deakin University, VIC, Australia
Title: Getting the brain to take its medicine

11.50: Professor Yoshikazu Nakamura
President and CEO, Ribomic Inc, Tokyo, Japan
Title: Aptamer therapeutics targeting pain and lung fibrosis

12.10: Dr Georg Mahlknecht
Immunology Department, Weizmann Institute of Science, Israel
Title: Aptamers targeting growth factor receptors

12.30: Dr Paloma H Giangrande
Associate Professor, Department of Internal Medicine, University of Iowa, USA
Title: RNA aptamer smart drug for the treatment of vascular injury

13.00: Lunch and networking

14.00: Professor Nagy Habib
Professor of Hepatobiliary Surgery, Faculty of Medicine, Department of Surgery & Cancer, Imperial College London, UK
Title: Targeted RNA activation

14.30: Dr Vittorio de Franciscis
Research Director, CNR Institute of Experimental Endocrinology and Oncology, Naples, Italy
Title: Combined selective targeting of cancer stem cells by aptamer-miRNA/antimiR conjugates 

15.00: Professor Dr Beatrix Suess
Synthetic Genetic Circuits, Technical University of Darmstadt, 03 064 Schnittspahnstraße 1064287, Darmstadt, Germany
Title: Control of alternative splicing by engineered riboswitches

15.30: Refreshment break, posters, exhibition, networking

16.00: Dr Thomas Schubert
2bind GmbH, Regensburg, Bavaria, Germany
Title: Characterisation of aptamer-target interactions using MicroScale Thermophoresis

16.30: Professor Dr Günter Mayer
Life and Medical Sciences (LIMES)- Institute, University of Bonn, Gerhard-Domagk-Str. 1, Bonn, Germany
Title: A modular approach to nucleobase-modified aptames

17.00: Professor Karolien De Wael
AXES Research Group, Department of Chemistry, Antwerp University, Belgium
Title: Electrochemical aptasensing devices

17.20: Dr Arnaud Buhot
University of Grenoble/CNRS/CAE, France
Title: Gold nanoparticles SPRi enhanced signal for small molecules detection with split aptamer

17.40: Dr Julian Tanner
Associate Professor, Department of Biochemistry, University of Hong Kong, China
Title: DNA aptamers for point-of-care malaria diagnosis – from crystal structure to clinical application using Aptamer Tethered Enzyme Capture (APTEC)

18.00: Dr Graeme Doran
Director of Genomic Assays, FireFly BioWorks, Cambridge, MA, USA
Title: Direct quantification of small nucleic acid delivery to tissues

18.30: Close

19.00: NETWORKING DINNER (By invitation or prior booking only)


Day 2, Wednesday, 01 April 2015

9.20: Dr Jean-Jacques Toulmé
Director, Institut Européen de Chimie et Biologie, Pessac, France
Title: Aptamer driven supra-molecular assembly

09.50 Dr David Porciani
NEST – Scuola Normale Superiore, Piazza San Silvestro 12 Pisa, Italy
Title: Aptamer-mediated co-delivery of doxorubicin and NF-kB decoy enhances chemosensitivity of pancreatic tumor cells

10.20: Dr Nebojsa Janjic
SomaLogic, Inc, 2945 Wilderness Place, Boulder, CO, USA
Title: Modified aptamers with enhanced chemical diversity as essential tools for biomedical research

10.40: Refreshment break, posters, exhibition, networking

11.10: Professor Weian Zhao
Assistant Professor, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA
Title: Microencapsulated aptamer sensors for digital quantification of blood biomarkers

11.30: Dr Maureen McKeague
Bioengineering Department, Stanford University, USA
Title: Advancing a development pipeline for RNA switches through scalable measurement platform

11.50: Dr Yoann Roupioz
University of Grenoble/CNRS/CAE, France
Title: On the use of aptamer microarrays as a platform for the exploration of human prothombin/thrombin conversion

12.10: Mr Nam Nguyen Quang
CEA, Molecular Imaging Research Center, France
Title: Improvement of aptamers combining doped-SELEX and next-generation sequencing

12.30: Lunch and close


Fully Automated In Vitro Aptamer Selection

Edward Barnes

Aptamer Solutions Ltd, Suite 2.80 – 2.87, Bio Centre, Innovation Way, Heslington, York, YO10 5NY, UKHozBox500x3

Semi-automated aptamer selection for biomarker discovery

Edward Barnes

Aptamer Solutions Ltd, Suite 2.80 – 2.87, Bio Centre, Innovation Way, Heslington, York, YO10 5NY, UKHozBox500x3

Next-generation analysis of deep sequencing data: Bringing light into the black box of SELEX experiments

M Blank and C Gröber

AptaIT GmbH, Munich, GermanyHozBox500x3

Identification of tumour specific aptamers by in vivo SELEX

Laia Civit1, Holger Weber2, Michael Kubbutat2, Günter Mayer1

1Life and Medical Sciences Institute, University of Bonn, Gerhard-Domagk Str. 1, 53121 Bonn, Germany

2Research Division ProQuinase, Breisacher Str. 117, 79106 Freiburg, GermanyHozBox500x3

The development of a drug delivery system using brain endothelial-specific non-antibody binding domains as blood brain barrier transport carriers

Mohammad Daas 1, David Male 1, Carol Midgley 1, George Thom 2, Carl Webster 2, Ignacio A Romero 1

Department of Life, Health, and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom

MedImmune, Milstein Building, Granta Park, Cambridge, CB21 6GH, United Kingdom


Selection of LNA-containing DNA aptamers against recombinant CD73

Nicola Derbyshire1, Ida C. Elle1, Kasper K. Karlsen1, Mikkel G. Terp2, Niels Larsen3, Ronni Nielsen4, Susanne Mandrup4, Henrik J. Ditzel2,5, Jesper Wengel1

1 Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark

2 Institute of Molecular Medicine, University of Southern Denmark, J. B. Winsløwsvej 25, 5000 Odense C, Denmark

3 Danish Genome Institute, Skt. Lucas Kirkeplads 8, 8000 Aarhus C, Denmark

4 Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark

5 Department of Oncology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, DenmarkHozBox500x3

Aptamer Biosensor Based on Fluorescence Resonance Energy Transfer for Multiplexed Pathogenic Bacteria Determination

Nuo Duan, Shijia Wu, Zhouping Wang

State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China


Aptamers Targeting Dendritic cells and Macrophages

Silvana Hassel1, Verena Schütte2, Susanne Schmidt2, Joachim Schultze2, Sven Burgdorf2 and Günter Mayer1

1Life and Medical Sciences (LIMES), University of Bonn, Gerhard-Domagk-Str. 1, Germany

2Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Str. 31, Germany


Phage Display and SELEX brought together – a bivalent aptamer-antibody conjugate for VEGFR specific targeting

Przemyslaw M Jurek, Marta Matusiewicz, Mateusz Piksa, Maciej P. Mazurek, Piotr Jakimowicz, Filip Jelen

Pure Biologics Ltd, Wroclaw, Poland


Selection and Identification of single-stranded DNA Aptamers Targeted to Cronobacter sakazakii

Hong-Seok Kim, Young-Ji Kim, Jung-Whan Chon, Dong-Hyeon Kim, Jin-Hyeok Yim, Dasom Choi, Il-byeong Kang and Kun-Ho Seo

Center for Food Safety, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, South Korea


Resampling of aptamer libraries based on aptamer family consensus motifs to isolate the highest affinity binders

Andrew B Kinghorn1, Julian A Tanner1

1Department of Biochemistry, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong SARHozBox500x3

Aptamer Mediated Uptake of Therapeutic Agents

Sven Kruspe1, Cindy Meyer2, Uli Hahn1

1University of Hamburg, Department Chemistry, Institute for Biochemistry and Molecular Biology, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany

2 Laboratory of RNA Molecular Biology; Howard Hughes Medical Institute; The Rockefeller University; New York, NY USAHozBox500x3

The use of a bi-functional aptamer to target brain metastases

Joanna Macdonald, Wei Duan and Sarah Shigdar

School of Medicine, Deakin University, Waurn Ponds, VIC, Australia, 3216

Isolation and characterization of RNA aptamer for P. falciparum cytoadherence


VideoScan AptaBead Array – Identification of optimized buffer/binding conditions for Aptamers using a Multiplex, High-throughput Screening Platform

Carsten Schmidt1, Christian Schröder2, Peter Schierack3, Stefan Rödiger1

1 InnoProfile-Transfer RG “Imagebased-assays”, Brandenburg University of Technology, Großenhainer Str. 57, 01968 Senftenberg, Germany

2 Chair of Molecular Biology, Brandenburg University of Technology, Großenhainer Str. 57, 01968 Senftenberg, Germany

3 Chair of Molecular Diagnostics, Brandenburg University of Technology, Großenhainer Str. 57, 01968 Senftenberg, GermanyHozBox500x3

Click-SELEX – A modular method enabling nucleobase-modified aptamers

Fabian Tolle and Günter Mayer

Life and Medical Sciences Institute (LIMES), University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, GermanyHozBox500x3

Detection of Small Molecules using Sandwich-type Enzyme-linked Aptamer Kissing Complex Assay (ELAKCA)

Benoît Chovelon1,2, Guillaume Durand3, Eric Dausse3, Jean-Jacques Toulmé3, Patrice Faure2,4, Eric Peyrin1*, Corinne Ravelet1

1CNRS UMR 5063, Department of Molecular Pharmacochemistry, University Grenoble Alpes, 38400 St Martin d’Hères, France

2 Département de Biochimie, Toxicologie et Pharmacologie, CHU de Grenoble site Nord – Institut de biologie et de pathologie, F-38041 Grenoble, France.

3 ARNA Laboratory, Inserm U869, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.

4Inserm U1042, Laboratory of hypoxy physiopathology study, University Grenoble Alpes, 38700 La Tronche, FranceHozBox500x3

An Improved Design of the Kissing Complex-based Aptasensor for the Detection of Adenosine

Emma Goux1, Samuele Lisi1, Corinne Ravelet1, Guillaume Durand2, Emmanuelle Fiore1, Eric Dausse2, Jean-Jacques Toulmé2 and Eric Peyrin1

CNRS UMR 5063, Department of Molecular Pharmacochemistry, University Grenoble Alpes, 38400 St Martin d’Hères, France

2 ARNA Laboratory, Inserm U869, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France


Selection and application of DNA aptamers against Shigella sonnei

Zhouping Wang, Nuo Duan, Shijia Wu

State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China


Aptamex kmirage – a bioinformatics application to compare next-gen sequencing SELEX data

Albert J Vilella,Willi Gottstein, Andy Ballard, Kasper Piskorski, Jesper Nissen, Weiyan Xiang, Lucy Colwell, Andrew Deonarine

Aptamex Limited, an Onto.it Software company, 62-66 Victoria Road, Cambridge, CB4 3DU, UK


Macrocyclic host-dye reporter for sensitive sandwich-type fluorescent aptamer sensor

Cheng YANG 1,2, Nicolas SPINELLI 2, Sandrine PERRIER 1, Eric DEFRANCQ 2 and Eric PEYRIN 1

1 Département de Pharmacochimie Moléculaire, Université Grenoble Alpes, CNRS UMR 5063, Grenoble, France

2 Département de Chimie Moléculaire, Université Grenoble Alpes, CNRS UMR5250, Grenoble, France

Aptamers 2015 Sponsors

Gold Sponsor and Exhibitor

AptamerGroup-logoTag-cmyk LinkedIn
Aptamer Solutions Ltd is a York based Biotechnology Company specialising in the custom selection of high-affinity and highly specific nucleic acid aptamers for use in the life sciences sector. Our proprietary automated high-throughput aptamer selection processes allow us to offer a flexible and competitive pricing structure for the development of RNA and DNA aptamers. In addition, we are about to launch a new complementary technology in the area of biomarker discovery.

Our proprietary aptamer based biomarker discovery platform and proprietary combinatorial libraries contain up to and over 1018 different molecules, this diversity and bespoke library design is fundamental to the success of the screening process. This technology enables us to greatly speed up the identification of novel biomarkers as well as diagnostics and/or therapeutic candidate molecules. This technology builds on one of the most powerful uses of aptamer technology, which is the ability for aptamers to be isolated against targets without any prior knowledge of the target.

Our aptamer-based proteomic technology identifies novel biomarkers within the cell surface (such as tumours, cell lines or stem cells) or in samples of biological fluids (such as, urine, plasma and saliva). The technology is versatile and can also be applied to viruses, bacteria, fungi or any other cell based materials or extracts. The discovery process is driven by identifying differences between sample population using enormous aptamer libraries. Samples are prepared based on broad classifications such as: disease vs normal; pre-metastatic vs. post metastatic cancers; pathogenic vs non-pathogenic fungi etc. The process is fast and efficient and identifies differences between ‘healthy’ and ‘diseased’ whilst simultaneously developing the affinity reagent. This cuts out many of the steps associated with traditional biomarker discovery processes.

Silver Sponsor


The 2bind GmbH, Regensburg, Germany, provides biophysical analyses of molecular interactions. We work with worldwide customers from pharma, biotech as well as universities on the characterization of molecular interactions in terms of binding affinities, stoichiometries and binding energetics. Our semi-automated platform based on the MicroScale Thermophoresis technology (MST) allows us to offer cost-efficient, precise and fast analyses of molecular interactions. The integrated quality controls of the MST system enable us to easily identify sticking and aggregation effects and to directly improve measurement conditions ensuring high quality data. In addition to immobilization-free measurements in free solution, MST offers free choice of buffer, allowing close to native measurements in sera and lysates. Besides the low sample consumption our customers benefit from the broad application range of the MST. With our strong expertise in assay development, the company established standardized assays to analyze aptamer-target interactions in semi-high throughput for the aptamer developing industry and scientists. Further MST services includes competition assays, binding site mapping assays and binding assays that simultaneously test multiple binding partners. Hence, our services based on the MST technology are perfectly suitable for the identification, characterization and optimization of aptamer-target interactions.