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Aptamers
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Aptamers 2019
03-04 April 2019, Oxford
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RNAi2013

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See you at:

Aptamers2014, (24-25 March 2014, Oxford, UK)

RNAi2014, (25-27 March 2014, Oxford, UK)

NGS 2014, (31 March-03 April 2014, Oxford, UK)

RNAi2013-Sponsors

 

Read RNAi2013 Report

RNAi2013 Speakers

Day-1: 19 March 2013

Professor Kaz Taira, Japan
Title: Identification of functional genes by ribozyme and shRNA libraries
Professor, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba; The University of Tokyo; Tokyo University & Graduate School of Social Welfare; and Nagase & Co Ltd, Tokyo, Japan

Dr Annaleen Vermeulen, USA
Title: Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens
Senior Scientist/R&D Manager, Thermo Fisher Scientific, USA

Professor Dr Georg Sczakiel, Germany
Title: Evidence suggesting involvement of target RNA in guide strand-loading of active Argonaute-2
Professor and Director, Institute of Molecular Medicine, University of Luebeck, Germany

Professor Achim Aigner, Germany
Title: RNAi, miRNA replacement or U1i: Various approaches for the knockdown of the oncogene Pim-1
Professor, Rudolf-Boehm-Institute for Pharmacology and Toxicology Clinical Pharmacology, University of Leipzig, Germany

Day-2: 20 March 2013

Dr Negar Babae, The Netherlands
Title: Identification of novel anti-angiogenic miRNAs and their therapeutic potential
Postdoctoral Scientist, Schiffelers Laboratory, UMC Utrecht, The Netherlands

Dr Dave Carter, UK
Title: Identification of a miRNA inducing cisplatin drug resistance in ovarian cancer
Senior Lecturer in Biomedcial Sciences, Department of Biological and Medical Sciences – Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK

Professor Paul Holvoet, Belgium
Title: MicroRNAs and mitochondrial stress in obesity
Professor and Head, Atherosclerosis and Metabolism Unit, University of Leuven, Belgium

Dr Paul Diehl, USA
Title: Pooled RNAi genetic screening to identify critical functional genes and novel drug targets
Director of Business Development, Cellecta, CA, USA

Technology Workshops

Sigma-Aldrich

Carl Zeiss

Dr Klaus Giese, Germany
Title: Development of liposomally-formulated siRNA for RNAi-based therapy: Atu027 for therapeutic application in oncology
CSO, Silence Therapeutics, Berlin, Germany

Professor Gilles Divita, France
Title: Peptide-based nanoparticles for targeted delivery of siRNA
Professor, Macromolecular Biochemistry Research Centre, CNRS-UMR, France

Dr Raymond Schiffelers, The Netherlands
Title: Intravenous delivery of novel anti-angiogenic miRNAs
Associate Professor, UMC Utrecht, The Netherlands

Dr Mike Gait, UK
Keynote Speaker
Title: Inhibition of microRNAs by PNA and LNA-based oligonucleotides
MRC Laboratory of Molecular Biology, Cambridge, UK

Dr Dmitry Samarsky, PR China
Title: RNAi and antisense oligonucleotide in vivo delivery for therapeutic applications
EVP, Technology & Business Development, RiboBio, PR China

Professor Andrew Miller, UK
Title: Old wine in new bottles” – constant innovation in delivery system design is essential to improve functional delivery of RNAi effectors
Professor of Biochemistry, Kings College London, UK

Day-3: 21 March 2013

9.00am: Dr Patrick Lu, USA
Title: The Prophylactic and Therapeutic Potentials of siRNA Inhibitors for Fighting Emerging Respiratory Viral Infections
CEO, Siranomics, USA

Professor Jens Kurreck, Germany
Title: RNAi-based combination therapies against viruses
Professor of Biochemistry, Technical University Berlin, Berlin, Germany

Dr Susanna Obad, Denmark
Title: Silencing of miR-122 for treatment of Hepatitis C
Drug Discovery Manager, Santaris Pharma, Denmark

Dr Jonathan Watts, UK
Title: Increased binding affinity by fluorinated oligonucleotides: origins and implications
Lecturer in Chemical Biology, University of Southampton, UK

Dr Kathia Zaleta-Rivera, USA
Title: Oligonucleotide therapeutic approaches for allele silencing of hMYL2-47K and hMYH7-403Q mutations in Hypertrophic Cardiomyopathy
Postdoctoral Research Scientist, Ashley Laboratory, Falk Cardiovascular Research Center, Stanford University School of Medicine, CA, USA

Dr Tom Roberts, UK
Title: Investigation of extracellular microRNAs in the mdx mouse
Postdoctoral Research Scientists, Wood Laboratory, Department of Physiology, Anatomy and Genetics, University of Oxford, UK

RNAi2013 Posters (Presenter*).

Pooled RNAi Genetic Screening to Identify Critical Functional Genes and Novel Drug Targets

Donato Tedesco, Kyle Bonneau, Mikhail Makhanov, Costas G. Frangou, Paul Diehl* and Alex Chenchik
Cellecta Inc, Mountain View, CA; Roswell Park Cancer Institute, Buffalo, NY

Epigenetic inactivation of direct transcriptional target microRNA of TP53 including mir-34a, mir-34b/c in Acute Promyelocytic Leukemia

HY Ng* and CS Chim
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong

Inhibition of influenza viral replication using siRNA delivered by pH-responsive peptides

Wanling Liang*, PN Lau, James Mason, Leo LM Poon and Jenny KW Lam
Department of Pharmacology & Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Institute of Pharmaceutical Science, King’s College London, United Kingdom

SYL1001: A New Treatment for Ocular Pain Associated to Dry Eye Syndrome based on RNAi Technology: Safety and Tolerance

Tamara Martínez*, Covadonga Pañeda, Victoria González, Verónica Ruz and Ana I Jiménez
Sylentis SAU, Parque Científico de Madrid, Tres Cantos 28760, Madrid, Spain

Understanding and building robust clinical assays to analyze microRNAs in biofluids

Antonio Sorrentino*, Thorarinn Blondal, Jan Stenvang, T Ørntoft, Nils Brunner, Claus Andersen, Hans J Nielsen, Peter Mouritzen
Exiqon A/S, Vedbæk, Denmark; University of Copenhagen, Copenhagen, Denmark; Aarhus University Hospital, Aarhus, Denmark; Hvidovre Hospital, Copenhagen, Denmark

We present the LNA™-based PCR technology designed to enable the robust detection of microRNAs in biofluids, and introduce our quality control and data analysis pipeline that we have developed to secure high quality reliable microRNA profiling data in a range of biofluid samples.

Identification of microRNA target sites in Kir2.1 3’ UTR by a novel dual-fluorescence assay

Janet Yarham*, Lyndsey Ferguson, Mary McGahon, David Simpson, Anthony Collins
Centre for Vision and Vascular Science, Queen’s University Belfast, Institute of Clinical Science, Block A, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, UK

Effects of LEA-12 gene silencing on survival, behaviour and development in the anhydrobiotic nematode Panagrolaimus superbus

Tiago Campos Pereira*, GustavoBorges, Cláudia Carolina Silva Evangelista, Ann Burnell and Alan Tunnacliffe
Dept of Biology, Faculty of Philosophy, Sciences and Languages of Ribeirão Preto, University of Sao Paulo (USP), Ribeirão Preto, SP, Brazil. 14040-901; Dept. of Biology, National University of Ireland, Maynooth, Ireland; Dept. of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

RNAi-mediated knockdown of a peroxiredoxin unveils its roles on oxidative stress resistance, fertility and morphology in the anhydrobiotic nematodePanagrolaimus superbus

Tiago Campos Pereira*, Cláudia Carolina Silva Evangelista, Ann Burnell and Alan Tunnacliffe
Dept of Biology, Faculty of Philosophy, Sciences and Languages of Ribeirão Preto, University of Sao Paulo (USP), Ribeirão Preto, SP, Brazil. 14040-901; Dept. of Biology, National University of Ireland, Maynooth, Ireland; Dept. of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

RNAi of a glutathione peroxidase in the nematode Panagrolaimus superbusreveals its role in oxidative stress during anhydrobiosis

Tiago Campos Pereira*, Giovanna Guidelli, Ann Burnell and Alan Tunnacliffe
Dept of Biology, Faculty of Philosophy, Sciences and Languages of Ribeirao Preto, University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil. 14040 901; Dept of Biology, National University of Ireland (NUI), Maynooth, Ireland; Dept of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

Development of a medium-scale RNAi-based platform to identify anhydrobiosis-related genes in the nematode Panagrolaimus superbus

Tiago Campos Pereira*, Thaís Fenz Araujo, Cláudia Carolina Silva Evangelista, Gustavo Borges, Ann Burnell and Alan Tunnacliffe
Dept of Biology, Faculty of Philosophy, Sciences and Languages of Ribeirão Preto, University of Sao Paulo (USP), Ribeirão Preto, SP, Brazil. 14040-901; Dept. of Biology, National University of Ireland, Maynooth, Ireland; Dept. of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

Virus-inspired Designer Polypeptides as Nanocarriers for RNA and Nucleic Acid Delivery

Armando Hernandez-Garcia*, Frits de Wolf, Martien Cohen-Stuart and Renko de Vries
Laboratory of Physical Chemistry and Colloid Science, Wageningen University; Food and Biobased Research, Wageningen University and Research Centre; Dutch Polymer Institute, The Netherlands

Binding of miR398 family to mRNA of superoxide dismutase genes in plants

Assyl Bari*, S Orazova and A Ivashchenko
Institute of Biology and Biotechnology Problems, al-Farabi Kazakh National University, Kazakhstan

miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2

Hai-Feng Zhang*, Li-Yan Xu, En-Min Li
The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, No.22, Xinling Road, Shantou 515041, Guangdong, China; Institute of Oncologic Pathology, Shantou University Medical College, No.22, Xinling Road, Shantou 515041, Guangdong, China; Department of Laboratory Medicine and Pathology, 5-096 Katz Building, University of Alberta, Edmonton, Alberta, T 6G 2E1, Canada

High-level expression of miR-378 alters the sensitivity of Cetuximab response in KRAS/BRAF mutation colorectal cancer

Weng Wen-Hui*, Leung Wai-Hung, Chen Jing-Jung, Chen Chien-Wei1, Hsu Hsi-Hsien, Pang See-Tong
Department of Chemical Engineering and Biotechnology and Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology: Division of colorectal surgery, Department of surgery, Mackey Memorial Hospital, Taipei, Taiwan: Divison of Urology, Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Conservation of miRNA33 function in lipid metabolism through evolution

Laure-Alix Clerbaux*, Isabelle Gerin, Olivier Haumont, Barbara Pachikian, Nathalie Delzenne, Ormond A MacDougald and Guido T Bommer
Laboratory for Physiological Chemistry, de Duve Institute, and Metabolism and Nutrition Research group, Louvain Drug Research Institute, Université catholique de Louvain, Belgium: Department of Internal Medicine and Molecular & Integrative Physiology, University of Michigan, USA

Gene KnockUp: Increasing translational intensity of targeted mRNA using SINEUP lncRNA constructs

Silvia Zucchelli, Michael Jones*, Laura Cimatti, Hazuki Takahashi, Hideki Yakushiji, Stefano Bio, Claudio Santoro, Piero Carninci and Stefano Gustincich 
SISSA, Trieste, Italy; University of Eastern Piedmont, Novara, Italy; TransSINE Technologies, Yokohama, Japan; Cell Guidance Systems, Cambridge, UK; RIKEN, Yokohama, Japan; Vita-Salute San Rafaele University, Milan, Italy

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