(Subject to change: The conference may finish slightly earlier or later than the advertised time)
Presentation language: English
Venue: The Jarvis Doctorow Hall, St Edmund Hall, Queen’s Lane, Oxford, UK
Time Zone: All times mentioned refer to British Standard Time (BST) – London/GMT
Password and links: Registered conference delegates will be sent joining information and conference access links a few days before the conference.
World Time Converters: https://greenwichmeantime.com and https://www.worldtimebuddy.com
NB: Due to the hybrid nature of the agenda and the wide geographical locations of our speakers, it may not have always been possible to group together related presentations.
0900: Registration and coffee
0950: Welcome and housekeeping
1000: Professor Dr Günter Mayer
Professor of Chemistry, University of Bonn, Life & Medical Sciences Institute (LIMES), Chemical Biology, Bonn, Germany
Click SELEX is a versatile method for identifying nucleobase-modified aptamers that bind to a range of targets both in vitro and in vivo
1020: Dr Elena Eremeeva
Postdoctoral Scientist, Centre for Agriculture and the Bioeconomy, School of Biology and Environmental Science, Queensland University of Technology, Gardens Point Campus, Brisbane, 4000, Queensland, Australia
Aptamers unleashed: from underdogs to universal molecular sensors
1040: Dr Julián Valero
Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark
Cryo-EM based engineering of multimeric RNA aptamer nanostructures for enhanced targeting
1100: Refreshment break, posters and networking
1130: Dr Ravi Mehta
Clinical Research Fellow, Department of Infectious Disease, Imperial College London; London, UK
Aptamer-based assays for detection of the viral biomarker 3’-deoxy-3’,4’-didehydro-cytidine
1150: Dr Usman Akhtar
Postdoctoral Scientist, Institut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris, France
Selection of modified aptamers exhibiting low-nanomolar Kd
1210: Mr Florian Blaser
Graduate Research Student , Competence Team Bioanalytics, Fraunhofer IZI-BB, Am Mühlenberg 13, 14476 Potsdam, Germany
A Long Journey from Conception Towards Validation: Development of an Aptamer Sandwich Assay Targeting Urokinase Plasminogen Activator in Human Urine
1230: Professor Dr Beatrix Suess
Professor, Synthetic Genetic Circuits, Technical University of Darmstadt, Darmstadt, Germany
Beyond the niche – Unlocking the full potential of synthetic riboswitches
1250: Dr Janis Hoetzel
Postdoctoral Scientist, Department of Biology, Technical University of Darmstadt, Darmstadt, Germany
What makes RNA switch? Case study on a new, regulatory doxycycline aptamer
1310: Lunch and networking
1410: Dr Eric Rovira Barreira
Postdoctoral Scientist, RNA biology and therapy Department, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), Pamplona, Spain
Structural characterization of a U1 snRNP riboswitch allows rational design of novel riboswitches for polyadenylation regulation in mammalian cells
1430: Professor Philip Johnson
Professor of Chemistry, Department of Chemistry, York University, Toronto, Ontario, Canada
Distinguishing specific from non-specific binding of small molecules by DNA aptamers using biophysical methods
1450: Dr Cameron Mackereth
Principal Investigator, University Bordeaux, Inserm U1212, ARNA Laboratory, Bordeaux, France
Structural characterization of DNA aptamer-small molecule complexes
1510: Professor José Martins
Professor, Faculty of Sciences, NMR and Structure Analysis Research Group, Ghent University, Ghent, Belgium
Beyond cartoons: molecular-level views of steroid binding by aptamers
1530: Professor Maureen McKeague
Assistant Professor of Chemistry, Department of Chemistry & Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada
A modular DNA-encoded platform for exploring chemical diversity in aptamer scaffolds
1550: Refreshment break, posters and networking
1610: Mr Yunus Kaiyum
Graduate Research Student, Department of Chemistry, York University, Toronto, ON, Canada
Destabilizing Thermodynamics of Aptamer–Ligand Recognition
1630: Dr Shanshan Yao
Postdoctoral Scientist, School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
AI-powered therapeutic aptamer drug discovery: targeting the CT-domain of CTGF for Duchenne Muscular Dystrophy
1650: Dr Justin Baker
Hedrick Adjunct Assistant Professor, Department of Mathematics, University of California, Los Angeles, USA
Leveraging Boltzmann secondary-structure ensembles of aptamers for explainable artificial intelligence and efficient in silico dynamics
1710: Dr Margaret Lange
Assistant Professor, Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA
Determinants of aptamer specificity for HIV-1 capsid assembly forms revealed by crosslinking mass spectrometry
1730: Dr Alix Bouvier-Müller
Postdoctoral Scientist, CEA, DRF, Institut of biology JACOB, Molecular Imaging Research Center (MIRCen), UMR 9199 CNRS, Université Paris Saclay, Fontenay aux roses 92335, France
Discrimination of α-synuclein fiber polymorphs using aptamer binding footprints (AptaFOOT-Seq)
1740: Dr Lisa Le Dortz
Postdoctoral Scientist, CEA, DRF, Institut of biology JACOB, Molecular Imaging Research Center (MIRCen), LPiA, Fontenay aux roses 92335, France
Improving Adeno-associated virus (AAVs) vectors purification : a novel affinity chromatography approach
1750: Close
1900: Networking dinner (further information will be sent by email)
1000: Dr Ana Díaz-Fernández
Assistant Professor, Department of Chemical and Analytical Chemistry. Universidad de Oviedo. Av. Julián Clavería, 8, 33006 Oviedo, Spain
Targeting soluble BCMA with DNA aptamers: from SELEX to computational assisted optimization
1020: Dr Christian Code
Chief Scientific Officer, ScienTek ApS, Fruebjergvej 3, Copenhagen, Denmark
From computer to sensor: an aptamer platform combining in-silico design, optical validation, and electrochemical detection of β-Parvalbumin
1040: Professor Valeria Milam
Assistant Professor, School of Materials Science & Engineering, Georgia Institute of Technology, Atlanta, GA, USA
A comparative study of aptamer selection platforms: SELEX vs CompELS
1100: Dr Paolo Climaco
Department of Mathematics, University of California, Los Angeles, USA
Unified 2D/3D Aptamer Tensor Descriptors and Pattern Discovery in SELEX
1120: Refreshment break, posters and networking
1250: Lunch, posters and networking
1330: Dr Tatsuo Adachi
Board Director, RIBOMIC Inc., Tokyo, Japan
Development of nucleic acid drug delivery systems using aptamers
1350: Professor Julian Tanner
Professor, School of Biomedical Sciences, University of Hong Kong, Hong Kong SAR, China
Aptamer-based biosensing – past to future
1410: Dr Federico Bosetto
Postdoctoral Scientist, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
DNA aptamers to disrupt the iron uptake in Pseudomonas aeruginosa as antimicrobial strategy
1430: Miss Caroline Doherty
MD-PhD Graduate Research Student, Medical Scientist Training Program, Mayo Clinic Graduate School of Biomedical Sciences and Mayo Clinic Alix School of Medicine, Rochester MN, USA
In vivo selection of anti-glioblastoma DNA aptamers for targeted intracellular toxin delivery using orthotopic patient-derived xenograft models
1450: Miss Jaya Lakshmi Narayanan
Graduate Research Student, Environmental Biotechnology Laboratory, Centre for Rural Development and Technology, Indian Institute of Technology, Delhi, India
Rapid SELEX-Driven Aptamer for detection of Multidrug-Resistant Pseudomonas aeruginosa
1510: Discussion and close